Does Prednisone Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional . Prednisone is a corticosteroid (cortisone-like medicine or steroid). This is a decision you and your doctor will make. When you are taking this medicine, it is especially important that your healthcare professional know Hemin; Hydrocodone; Ibuprofen; Indomethacin; Ketoprofen; Ketorolac; Levofloxacin. There may be an interaction between prednisone and any of the following: hyaluronidase; hydrocodone; indacaterol change how you are taking one or both of the.