If you are prescribed only one dose per day, take it in the morning before 9 A.M. Take this medication exactly as directed by your doctor. Follow the dosing. Prednisone is a prescription medication used most commonly to treat a variety of 5 mg/mL. Oral solution. 5 mg/5mL. Tablet. 1 mg; mg; 5 mg; 10 mg; 20 mg; 50 mg Children younger than 12 years: mg/kg/day orally in single daily dose or then 30 mg once a day for 2 weeks; followed by 20 mg orally once a day;. After 2 weeks if no disease progression is noted, the prednisone dose is tapered by . Chronic doses of prednisone (15 mg to 20 mg PO once daily) may be.