Learn about the potential side effects of prednisone. Abdominal distention, abdominal pain, constipation, diarrhea, gastric irritation, nausea. Find patient medical information for Prednisolone Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. In some cases, people find that taking prednisone can lead to weight gain. For those that are underweight because of their health it can be.