Steroids can be used to make your life more comfortable or to even save your life. But they may also have dangerous drug interactions. Prednisone. medications are known to interact with prednisone. Includes amlodipine, lisinopril, metformin. Learn about Prednisone (Prednisone Tablets, USP) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related. Because it suppresses the immune system, prednisone may also be used in dogs to manage immune-system source such as allergiesasthmalupus, and other disorders. Lesson Summary Let's review this lesson's content. There prexnisone long term side effects which may occur, so it is best to stop taking the medication when it is possible. Understanding Steroids. Q: Does 2 mg daily of prednisone do any damage to bones? Akorn, Inc.